|
T19654 |
Guanoclor
|
VATENSOL |
Others
|
|
Guanoclor (VATENSOL) (INN), also known as guanochlor, is a sympatholytic drug. It is known to bind to non-adrenergic sites in pig kidney membranes. |
|
T13383 |
Zamicastat
|
BIA 5-1058 |
BCRP
,
Hydroxylase
,
P-gp
|
|
Zamicastat (BIA 5-1058) is an inhibitor of dopamine β-hydroxylase (DBH), and is also a concentration-dependent dual inhibitor of P-gp and BCRP(IC50 values of 73.8 μM and 17.0 μM, respectively). |
|
T6604 |
Nepicastat hydrochloride
|
Nepicastat HCl,RS-25560-197 hydrochloride,SYN-117 hydrochloride,Nepicastat (SYN-117) HCl |
Hydroxylase
|
|
Nepicastat hydrochloride (RS-25560-197 hydrochloride) is an effective and specific inhibitor, which is used for bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, respectively.The affinity of Nepicasta... |
|
T61214 |
EWP 815
|
|
Phosphatase
,
Hydroxylase
|
|
EWP 815 is a disulfiram analogue that functions as a powerful inhibitor of Ins(1,4) P 2 phosphatase, Ins(1,4,5) P 3 5-phosphatase, and dopamine β-hydroxylase activity [1] [2]. |
|
T11238L |
Etamicastat hydrochloride
|
BIA 5-453 hydrochloride |
Dehydrogenase
|
|
Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a peripherally selective dopamine beta-hydroxylase inhibitor that reduces hypertension. |
|
T30615 |
Bupicomide
|
|
Hydroxylase
|
|
Bupicomide is a dopamine beta hydroxylase inhibitor with antihypertensive and vasodilatory activity that reduces 14C-norepinephrine biosynthesis of 14C-dopamine and can be used to study hypertension. |
|
T50049 |
4-Methylhistamine hydrochloride
|
|
Others
|
|
4-Methylhistamine hydrochloride has been shown to inhibit the activity of copper-dependent enzymes such as tyrosinase and dopamine beta-hydroxylase and has also been shown to modulate the expression of genes involved in ... |
|
T71942 |
3-Allylphenol
|
|
|
|
3-Allylphenol is an inhibitor of dopamine β-hydroxylase (DBH; Ki = 12 mM). |
|
T11238 |
Etamicastat
|
BIA 5-453 |
Dehydrogenase
|
|
Etamicastat can be used in the research of cardiovascular diseases. Etamicastat (BIA 5-453) is a potent and reversible dopamine-β-hydroxylase (DBH) inhibitor with an IC50 value of 107 nM. |
|
T60633 |
Nepicastat
|
|
|
|
Nepicastat (SYN117) is a selective, potent, and orally active dopamine-beta-hydroxylase inhibitor which can cross the blood-brain barrier (BBB). Nepicastat (SYN117) produces concentration-dependent inhibition of bovine a... |
|
T36207 |
Methylspinazarin
|
|
|
|
Methylspinazarin is a naphthoquinone bacterial metabolite that has been found in Streptomyces and is an inhibitor of catechol O-methyltransferase (COMT; IC50 = 0.8 μg/ml).1 It is selective for COMT over tyrosine hydroxyl... |
|
T6356 |
(R)-Nepicastat HCl
|
RS-25560-198 HCl |
Hydroxylase
|
|
(R)-Nepicastat HCl (RS-25560-198 HCl), the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for tw... |
